Toxicity of Sodium Nitroprusside as a Hypotensive Agent
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چکیده
منابع مشابه
The use of sodium nitroprusside as a hypotensive agent in plastic surgery.
THE use of sodium nitroprusside for hypotension during plastic surgical operations has been investigated at the Queen Victoria Hospital, East Grinstead, in a series of twelve cases. An attempt has been made to compare its effectiveness with that of the pharmacological blockers, and to determine whether controls such as posture and respiration are similarly responsible for its hypotensive action...
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1. The effects of graded intravenous infusions of sodium nitroprusside on resting blood pressure and heart rate and on the reflex changes in these variables evoked by a standardized Valsalva manoeuvre were studied in six normal subjects. The effects of nitroprusskle on the above variables were also studied after pretreatment with captopril, to allow assessment of the role of angiotensin 11. 2. ...
متن کاملFurther investigations regarding the toxicity of sodium nitroprusside.
Sodium nitroprusside is a valuable vasodilator, but its use has been curtailed because of numerous reports that, in the presence of blood, nitroprusside decomposes with release of toxic cyanide. We have examined the release of cyanide in terms of the known chemistry of nitroprusside and suggest that photochemical decomposition of nitroprusside and (or) its metabolism in vivo invalidates the ana...
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AHLQUIST (1948) suggested that adrenergic activity is divisible into alpha and beta groups. The former is concerned mainly with contraction of smooth muscle, including vasoconstriction in some areas-noradrenaline is almost exclusively an alpha substance. The latter includes adrenergic effects on the heart and relaxation of bronchial muscles-isoprenalin restricts itself almost entirely to such a...
متن کاملSodium Nitroprusside Injection
Except when used briefly or at low (< 2 mcg/kg/min) infus ion rates , sodium nitropruss ide gives rise to important quantities of cyanide ion, which can reach toxic, potentially lethal levels (see WARNINGS). The usual dose rate is 0.5 to 10 mcg/kg/min, but infus ion at the maximum dose rate should never las t more than 10 minutes . If blood pressure has not been adequately controlled after 10 m...
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ژورنال
عنوان ژورنال: Journal of UOEH
سال: 1979
ISSN: 0387-821X,2187-2864
DOI: 10.7888/juoeh.1.507